Genetic Analysis Dashboard

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Overall Genetic Risk Score

8.5/10

HIGH COMPLEXITY - Multiple pathway impairments requiring specialized management

5 Critical Variants
7 Moderate Impact
3 Protective

Methylation Pathway Analysis

Critical for DNA repair, neurotransmitter production, detoxification, and cardiovascular health

MTHFR
rs1801131
Folate → Methylfolate
A1298C - Reduced BH4
BHMT
rs567754 + rs651852
Betaine → Methionine
Down-regulated
MTRR
rs1801394
B12 Recycling
Reduced B12 remethylation
CBS
rs1801181
Homocysteine → Cysteine
Increased Activity
COMT
rs4633
Neurotransmitter breakdown
Reduced Activity
PEMT
rs12325817 + rs7946
Choline Synthesis
Reduced Synthesis
Folate Methylfolate Methionine SAMe Homocysteine Cysteine MTHFR ↓ MTR ↓ MAT ↓ CBS ↑
🧠

Neurological Impact

  • Reduced neurotransmitter synthesis
  • Increased anxiety/depression risk
  • Poor stress tolerance
  • Brain fog and fatigue
❤️

Cardiovascular Impact

  • Elevated homocysteine
  • Increased clotting risk
  • Endothelial dysfunction
  • Higher CVD risk
🔄

Metabolic Impact

  • Poor toxin clearance
  • Hormone imbalances
  • Energy production issues
  • DNA repair deficiency

Methylation Support Protocol

PRIMARY SUPPLEMENTS:

Methylfolate 2000mcg, Methyl-B12 10,000mcg, TMG 2000mg, SAMe 400mg

COFACTORS:

P5P (B6) 50mg, Riboflavin 100mg, Magnesium 400mg, Zinc 30mg

DIETARY SUPPORT:

High choline foods, leafy greens, limit protein to 60-70g/day (CBS upregulation)

AVOID:

Folic acid (synthetic), excessive methionine, high sulfur foods when symptomatic

Severely Impaired
Moderately Reduced
Normal/Protective