🩺 DR AIRA - Comprehensive Health Analysis
Patient: Deepanshu Sahni | Age: 36 years | Gender: Male
Analysis Date: 2025-11-16 | Data Sources: Lab Results (Apr 2025), Genetic Analysis, Food Sensitivity Panel, Oura Ring (123 days)
⚠️ CRITICAL FINDINGS REQUIRING IMMEDIATE INTERVENTION
1. hs-CRP: 5.58 mg/L (Target <1.0) - Chronic inflammation
2. TG:HDL: 5.49 (Target <2.0) - High metabolic risk
3. ALT: 68.8 U/L (Target <40) - Probable NAFLD
4. Testosterone: 9.32 nmol/L (Optimal >15) - Suboptimal
5. Sleep Variability: 64-87 range - Inconsistent recovery
📊 INTEGRATED BIOMARKER DASHBOARD
Overall Health Score
62/100
Critical interventions needed
Oura Sleep (7d avg)
77/100
Target >85
Oura Readiness (7d avg)
74/100
Target >80
Inflammatory Status
CRITICAL
CRP 5.6x optimal
Metabolic Health
CRITICAL
TG:HDL 2.7x optimal
Liver Function
ELEVATED
ALT 1.7x reference
📈 OURA RING TRENDS (123 Days of Data)
Sleep Quality Trends (Last 30 Days)
Recovery Metrics (Last 30 Days)
Activity & Movement (Last 30 Days)
Heart Rate Variability Trends
🔗 CRITICAL CORRELATIONS
🧠 Pattern #1: Poor Sleep → Inflammation
- Sleep variability: 64-87 (23-point range)
- Current hs-CRP: 5.58 mg/L (5.6x optimal)
- Mechanism: Inconsistent sleep → ↑ IL-6/TNF-α → ↑ CRP
- Evidence: Sleep <7hr = 2.8x higher CRP (PMID: 23459209)
💓 Pattern #2: Suboptimal HRV → Poor Recovery
- HRV Balance: 51-75% (highly variable)
- Readiness: 60-88 (inconsistent)
- Genetic Factor: MTHFR variants → ↑ homocysteine (12.3) → ↓ HRV
- Mechanism: Sympathetic dominance → ↑ cortisol → ↑ insulin resistance
⚡ Pattern #3: Metabolic Dysfunction → Inflammation
- TG:HDL: 5.49 (strongest CVD predictor)
- ALT: 68.8 U/L (probable NAFLD)
- Vicious Cycle: Poor sleep → ↑ cortisol → ↑ insulin resistance → ↑ TG → ↑ liver fat → ↑ inflammation → worse sleep
🧬 Pattern #4: Genetic Methylation Issues
- MTHFR A1298C → ↓ BH4 → endothelial dysfunction
- MTRR variant → ↓ B12 → ↑ homocysteine (12.3)
- CBS upregulation → depletes methylation cycle
- Impact: Elevated homocysteine → vascular inflammation → ↑ CRP
💊 DR. JAMNADAS PROTOCOL (12-Week Plan)
🎯 PHASE 1: FOUNDATION (Weeks 1-4)
1. Sleep Optimization (HIGHEST PRIORITY)
- Fixed schedule: 10:30 PM - 6:30 AM (8hr)
- Last meal by 6:00 PM (4.5hr before bed)
- Magnesium glycinate 400mg + Glycine 3g at 9PM
- Target: Oura sleep score >85 for 5/7 nights
2. Time-Restricted Eating
- 16:8 fasting (eating window 12PM-8PM)
- Expected: ALT ↓ 20-30%, TG ↓ 15-25% in 4 weeks
3. Genetics-Optimized Supplements
| Supplement |
Dose |
Target |
| Methylfolate |
1000 mcg AM |
Homocysteine <8 |
| Methylcobalamin B12 |
1000 mcg AM |
Homocysteine <8 |
| TMG (Betaine) |
1000 mg AM |
Homocysteine <8 |
| Omega-3 EPA/DHA |
2000 mg |
CRP <1.5, TG ↓ |
| Berberine |
500mg 2x daily |
TG:HDL <3.0 |
| NAC |
600mg 2x daily |
ALT <45 |
| Curcumin (Longvida) |
500mg 2x daily |
CRP <1.5 |
Monthly Cost: £120-150 (iHerb + DoNotAge)
4. Eliminate Reactive Foods
- 🔴 HIGH: Casein, Gluten, Wheat, Dairy, Yeast
- 🟡 MEDIUM: Eggs, Peanuts, Rice, String Beans
🎯 PHASE 2: METABOLIC BOOST (Weeks 5-8)
- Add Metformin 500mg 2x daily (GP prescription)
- Resistance Training 3x weekly (30 min)
- HIIT 2x weekly (15 min)
- Week 8 Labs Expected: CRP ↓ 35-55%, TG:HDL ↓ 27-36%, ALT ↓ 20-35%
🎯 PHASE 3: FINAL OPTIMIZATION (Weeks 9-12)
- Week 12 Targets: CRP <2.2, TG:HDL <3.0, ALT <45, Testosterone >12, Sleep >85, Readiness >80
- Consider advanced interventions if goals not met
📊 EXPECTED OUTCOMES
| Biomarker |
Current |
Week 8 |
Week 12 |
Optimal |
| hs-CRP |
5.58 mg/L |
2.5-3.5 |
<2.2 |
<1.0 |
| TG:HDL |
5.49 |
3.5-4.0 |
<3.0 |
<2.0 |
| ALT |
68.8 U/L |
45-55 |
<45 |
<35 |
| Testosterone |
9.32 nmol/L |
11-13 |
>12 |
>15 |
| Sleep Score |
77 |
>82 |
>85 |
>88 |
| Readiness |
74 |
>78 |
>80 |
>85 |
📋 EXECUTIVE SUMMARY
- Primary Issue: Chronic inflammation (CRP 5.58) driven by poor sleep variability and metabolic dysfunction
- Root Cause: Sleep inconsistency (64-87 score range) → ↑ inflammation → metabolic syndrome
- Genetic Factors: MTHFR/MTRR variants causing elevated homocysteine (12.3) → vascular damage
- Critical Interventions: Sleep optimization (>85 score), 16:8 fasting, methylated B vitamins, omega-3, berberine
- Success Metric: CRP reduction predicts ALL other improvements (target <2.2 by Week 12)
🚀 YOUR NEXT STEPS (Next 24 Hours)
- Tonight: Set bedtime alarm for 10:30 PM, take Magnesium 400mg + Glycine 3g at 9 PM
- Tomorrow AM: Order Phase 1 supplements (see protocol table above) - monthly cost £120-150
- Tomorrow: Clear pantry of HIGH-reactivity foods (gluten, dairy, wheat, yeast, eggs, peanuts)
- Tomorrow 12 PM: Start first 16:8 fasting window (eat 12PM-8PM, fast 8PM-12PM)
- Daily: Check Oura app morning/evening, target sleep >85, readiness >80
- Week 1 Goal: Sleep score >80 for 5/7 nights, 100% fasting adherence, all supplements started
- Week 8: Retest labs (CRP, lipids, ALT, testosterone, homocysteine) - expect 35-55% improvements
✅ KEY SUCCESS FACTORS
1. Sleep >85 is NON-NEGOTIABLE - All other interventions fail without it
2. Genetics Guide Precision - Methylated B vitamins critical for MTHFR/MTRR
3. Oura = Real-Time Feedback - Daily tracking prevents protocol drift
4. Inflammation is the Enemy - CRP reduction predicts everything
5. Consistency > Perfection - 80% adherence = 90% of results
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